AUTHOR=Bjorefeldt Andreas , Illes Sebastian , Zetterberg Henrik , Hanse Eric TITLE=Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies JOURNAL=Frontiers in Neural Circuits VOLUME=12 YEAR=2018 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2018.00005 DOI=10.3389/fncir.2018.00005 ISSN=1662-5110 ABSTRACT=
The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits