AUTHOR=Chambers Daniel B. , Androschuk Alaura , Rosenfelt Cory , Langer Steven , Harding Mark , Bolduc Francois V. TITLE=Insulin signaling is acutely required for long-term memory in Drosophila JOURNAL=Frontiers in Neural Circuits VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2015.00008 DOI=10.3389/fncir.2015.00008 ISSN=1662-5110 ABSTRACT=

Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies.