AUTHOR=Connelly William M., Errington Adam C., Di Giovanni Giuseppe , Crunelli Vincenzo 

TITLE=Metabotropic regulation of extrasynaptic GABAA receptors

JOURNAL=Frontiers in Neural Circuits

VOLUME=7

YEAR=2013

URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2013.00171

DOI=10.3389/fncir.2013.00171

ISSN=1662-5110

ABSTRACT=<p>A large body of work now shows the importance of GABA<sub>A</sub> receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under regulation. Here we review the mechanisms by which tonic inhibition is known to be modulated, and outline the potential behavioral consequences of this modulation. Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the tonic GABA<sub>A</sub> current, and how G-protein coupled receptors can regulate tonic inhibition through these effectors. We then speculate about the possible functional consequences of regulating the magnitude of the tonic GABA<sub>A</sub> current.</p>