AUTHOR=Asrican Brent , Augustine George J , Berglund Ken , Chen Susu , Chow Nicholas , Deisseroth Karl , Feng Guoping , Gloss Bernd , Hira Riichiro , Hoffmann Carolin , Kasai Haruo , Katarya Malvika , Kim Jinsook , Kudolo John , Lee Liming , Lo Shun-Qiang , Mancuso James , Matsuzaki Masanori , Nakajima Ryuichi , Qui Li , Tan Gregory , Tang Yanxia , Ting Jonathan T. , Tsuda Sachiko , Wen Lei , Zhang Xuying , Zhao Shengli TITLE=Next-generation transgenic mice for optogenetic analysis of neural circuits JOURNAL=Frontiers in Neural Circuits VOLUME=7 YEAR=2013 URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2013.00160 DOI=10.3389/fncir.2013.00160 ISSN=1662-5110 ABSTRACT=

Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.