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ORIGINAL RESEARCH article
Front. Netw. Physiol.
Sec. Networks in the Brain System
Volume 5 - 2025 | doi: 10.3389/fnetp.2025.1539682
This article is part of the Research TopicThe Network Theory of Epilepsy at TwentyView all 14 articles
Preictal Connectivity Dynamics: Exploring Inflow and Outflow in iEEG Networks
Provisionally accepted
Amirhossein Jahani1,2
Camille Bégin1Denahin Hinnoutondji Toffa1,2
Sami Obaid1,2
Dang Khoa Nguyen1,2
Elie Bou Assi1,2*- 1Montreal University, Montreal, Canada
- 2University of Montreal Hospital Centre (CRCHUM), Montreal, Quebec, Canada
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Focal resective surgery can be an effective treatment option for patients with refractory epilepsy if the seizure onset zone is accurately identified through intracranial EEG recordings. The traditional concept of the epileptogenic zone has expanded to the notion of an epileptogenic network, emphasizing the role of interconnected brain regions in seizure generation. Precise delineation of this network is essential for optimizing surgical outcomes. Over the past three decades, several quantitative connectivity methods have been developed to study the interactions between the seizure onset zone and noninvolved regions. Despite these advances, the mechanisms governing the transition from interictal to ictal periods remain poorly understood. In this study, we investigated preictal interactions between the seizure onset zone and the broader network using directed connectivity measures. We evaluated their effectiveness in identifying seizure onset zones using a multicenter intracranial EEG dataset, encompassing 243 seizures from 61 patients.
Keywords: intracranial EEG, inflow/outflow dynamics, Seizure onset zone, Preictal period, Network physiology
Received: 04 Dec 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Jahani, Bégin, Toffa, Obaid, Nguyen and Bou Assi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Elie Bou Assi, Montreal University, Montreal, Canada
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