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REVIEW article

Front. Netw. Physiol.
Sec. Networks of Dynamical Systems
Volume 4 - 2024 | doi: 10.3389/fnetp.2024.1483401
This article is part of the Research Topic Insights in Networks of Dynamical Systems, Vol II View all 5 articles

Emerging Cancer Therapies: Targeting Physiological Networks and Cellular Bioelectrical Differences with Non-Thermal Systemic Electromagnetic Fields in the Human Body -A Comprehensive Review

Provisionally accepted
Frederico Costa Frederico Costa 1*Bertram Wiedenmann Bertram Wiedenmann 2Eckehard Schöll Eckehard Schöll 3Jack Adam Tuszynski Jack Adam Tuszynski 4,5,6
  • 1 Hospital Sirio Libanes, São Paulo, Brazil
  • 2 Charité University Medicine Berlin, Berlin, Baden-Wurttemberg, Germany
  • 3 Institut für Theoretische Physik, Technische Universität Berlin, Berlin, Germany
  • 4 Department of Physics, Faculty of Science, University of Alberta, Edmonton, Alberta, Canada
  • 5 DIMEA, Politecnico di Torino, Turin, Italy
  • 6 Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Silesian, Poland

The final, formatted version of the article will be published soon.

    A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between normal and cancer cell counterparts. This opportunity can be explored as a novel treatment modality in Oncology. Cancer cells exhibit autonomous oscillations, deviating from normal rhythms. In this context, a shift from a static view of cellular processes is required for a better understanding of the dynamic connections between cellular metabolism, gene expression, cell signaling and membrane polarization as states in constant flux in realistic human models. In oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects. This review aims to show how non-thermal systemic radiofrequency electromagnetic fields leads to promising therapeutic responses at cellular and tissue levels in humans, supporting this newly emerging cancer treatment modality with early favorable clinical experience specifically in advanced cancer.

    Keywords: Network physiology, Non-thermal, Electromagnetic Fields, Radiofrequency, cancer treatment, Cancer cells, oscillations, resonance

    Received: 19 Aug 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Costa, Wiedenmann, Schöll and Tuszynski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Frederico Costa, Hospital Sirio Libanes, São Paulo, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.