Skip to main content

REVIEW article

Front. Netw. Physiol.
Sec. Networks in the Brain System
Volume 4 - 2024 | doi: 10.3389/fnetp.2024.1462672
This article is part of the Research Topic The Network Theory of Epilepsy at Twenty View all 12 articles

Networks Through the Lens of High-Frequency Oscillations

Provisionally accepted
Aline Herlopian Aline Herlopian 1,2*
  • 1 Yale University, New Haven, United States
  • 2 School of Medicine, Yale University, New Haven, Connecticut, United States

The final, formatted version of the article will be published soon.

    To date, there is no neurophysiologic or neuroimaging biomarker that can accurately delineate the epileptogenic network. High-frequency oscillations (HFO) have been proposed as biomarkers for epileptogenesis and the epileptogenic network. The pathological HFO has been associated with areas of seizure onset and epileptogenic tissue. Several studies have demonstrated that the resection of areas with high rates of pathological HFO is associated with favorable postoperative outcomes. Recent studies have demonstrated the spatiotemporal organization of HFO into networks and their potential role in defining epileptogenic networks. Our review will present the existing literature on HFO-associated networks, specifically focusing on their role in defining epileptogenic networks and their potential significance in surgical planning.

    Keywords: high-frequency oscillations, ripples, fast ripples, network, propagation, connectivity, biomarker

    Received: 10 Jul 2024; Accepted: 22 Oct 2024.

    Copyright: © 2024 Herlopian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Aline Herlopian, Yale University, New Haven, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.