AUTHOR=Cui Cathy K. , Wong Wui-Kwan , Wong Chong H. , Gill Deepak , Fong Michael W. K. 

TITLE=Case Report: Focal, generalized, or both: does generalized network involvement preclude successful epilepsy surgery?

JOURNAL=Frontiers in Network Physiology

VOLUME=4

YEAR=2024

URL=https://www.frontiersin.org/journals/network-physiology/articles/10.3389/fnetp.2024.1425329

DOI=10.3389/fnetp.2024.1425329

ISSN=2674-0109

ABSTRACT=<p>We present two cases with focal seizures where scalp electroencephalography (EEG) had prominent features of a developmental and epileptic encephalopathy (DEE): Case 1: a 17-year-old male with complex motor seizures whose EEG demonstrated a slow spike-and-wave pattern and generalized paroxysmal fast activity (GPFA). Case 2: a 12-year-old male with startle-induced asymmetric tonic seizures whose EEG also had a slow spike-and-wave pattern. Both patients had intracranial EEG assessment, and focal cortical resections resulted in long-term seizure freedom and resolution of generalized findings. These cases exemplify patients with focal epilepsy with networks that share similarities to generalized epilepsies, and importantly, these features did not preclude curative epilepsy surgery.</p>