AUTHOR=Venkadesh Siva , Shaikh Asmir , Shakeri Heman , Barreto Ernest , Van Horn John Darrell TITLE=Biophysical modulation and robustness of itinerant complexity in neuronal networks JOURNAL=Frontiers in Network Physiology VOLUME=4 YEAR=2024 URL=https://www.frontiersin.org/journals/network-physiology/articles/10.3389/fnetp.2024.1302499 DOI=10.3389/fnetp.2024.1302499 ISSN=2674-0109 ABSTRACT=

Transient synchronization of bursting activity in neuronal networks, which occurs in patterns of metastable itinerant phase relationships between neurons, is a notable feature of network dynamics observed in vivo. However, the mechanisms that contribute to this dynamical complexity in neuronal circuits are not well understood. Local circuits in cortical regions consist of populations of neurons with diverse intrinsic oscillatory features. In this study, we numerically show that the phenomenon of transient synchronization, also referred to as metastability, can emerge in an inhibitory neuronal population when the neurons’ intrinsic fast-spiking dynamics are appropriately modulated by slower inputs from an excitatory neuronal population. Using a compact model of a mesoscopic-scale network consisting of excitatory pyramidal and inhibitory fast-spiking neurons, our work demonstrates a relationship between the frequency of pyramidal population oscillations and the features of emergent metastability in the inhibitory population. In addition, we introduce a method to characterize collective transitions in metastable networks. Finally, we discuss potential applications of this study in mechanistically understanding cortical network dynamics.