AUTHOR=Romero-Ortuño Román , Martínez-Velilla Nicolás , Sutton Richard , Ungar Andrea , Fedorowski Artur , Galvin Rose , Theou Olga , Davies Andrew , Reilly Richard B , Claassen Jurgen , Kelly Áine M , Ivanov Plamen Ch. TITLE=Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults JOURNAL=Frontiers in Network Physiology VOLUME=1 YEAR=2021 URL=https://www.frontiersin.org/journals/network-physiology/articles/10.3389/fnetp.2021.712430 DOI=10.3389/fnetp.2021.712430 ISSN=2674-0109