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BRIEF RESEARCH REPORT article

Front. Nephrol.
Sec. Kidney Transplantation
Volume 4 - 2024 | doi: 10.3389/fneph.2024.1467669

Analyzing body composition in living kidney donors: impact on post-transplant kidney function

Provisionally accepted
Evelien Quint Evelien Quint Lisa Westenberg Lisa Westenberg Gertrude Nieuwenhuijs Gertrude Nieuwenhuijs Eva van den Broek Eva van den Broek Marcel Zorgdrager Marcel Zorgdrager TransplantLines Investigators TransplantLines Investigators Alain Viddeleer Alain Viddeleer Stephan J. Bakker Stephan J. Bakker Ijla Nolte Ijla Nolte Marco van Londen Marco van Londen Robert Pol Robert Pol *
  • University Medical Center Groningen, Groningen, Netherlands

The final, formatted version of the article will be published soon.

    Living donor kidney transplantation boasts superior patient and graft survival rates compared to deceased donor kidney transplantation. However, the impact of living donor body composition (BC) on post-transplant kidney function remains uncertain. In a cohort of 293 living kidney donor-recipients pairs, we utilized linear mixed model analyses, adjusted for time and including a multiplicative interaction term of time with the donor body composition measure, and found no significant associations between any donor BC measure and the annual change in recipient post-transplantation estimated glomerular filtration rate (eGFR) [donor body mass index (BMI): Β=-0.01, 95%CI -0.13; 0.11, p=0.88; donor waist circumference: Β=0.02, 95%CI -0.02; 0.06, p=0.38; donor skeletal muscle index: B=-0.02, 95%CI -0.07; 0.04, p=0.63; donor skeletal muscle radiation attenuation: B=-0.002, 95%CI -0.06; 0.06, p=0.96; donor visceral adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.93; donor subcutaneous adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.94; donor intramuscular adipose tissue index: B=-0.12, 95%CI -0.29; 0.06, p=0.19; donor total abdominal adipose tissue index: B=-0.001, 95%CI -0.01; 0.01, p=0.89]. Our study suggests that pre-donation BC does not affect post-transplantation recipient eGFR in donor populations with a BMI below 35 kg/m2. 

    Keywords: living donor kidney transplantation, Body Composition, Kidney function, Body Mass Index, Computed tomography

    Received: 20 Jul 2024; Accepted: 01 Nov 2024.

    Copyright: © 2024 Quint, Westenberg, Nieuwenhuijs, van den Broek, Zorgdrager, Investigators, Viddeleer, Bakker, Nolte, van Londen and Pol. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Robert Pol, University Medical Center Groningen, Groningen, Netherlands

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.