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ORIGINAL RESEARCH article

Front. Nephrol.
Sec. Clinical Research in Nephrology
Volume 4 - 2024 | doi: 10.3389/fneph.2024.1465380

The Impact of SLCO1B1 polymorphisms on Homocysteine Concentrations: Evidence for a Stronger Association in Male

Provisionally accepted
Xinyuan Hu Xinyuan Hu Yanfang Jiang Yanfang Jiang *
  • Genetic Diagnosis Center, First Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Background: Homocysteine (Hcy) is a risk factor for stroke. In this study, we investigated the relationship between gene polymorphisms, particularly SLCO1B1, and homocysteine (Hcy) concentrations in ischemic stroke patients, with a focus on identifying potential risk factors for elevated Hcy levels.. Methods. 177 Ischemic stroke patients underwent Pharmacogenomics (PGx) sequencing included 99 Single Nucleotide Polymorphisms (SNPs) test were included from September 2022 to November 2023 in the hospital. Logistic regression analysis was used to analyse the relationship between clinical characteristic, SNPs and Hcy concentrations. The substudy including 207 Ischemic stroke and 244 with non-stroke patients only underwent SLCO1B1c.521T>C polymorphism to further demonstrate the role of SLCO1B1c.521T>C polymorphism and homocysteine.Higher Hcy concentrations were observed in men compared to women. Univariate logistic analysis identified gender, GGT concentrations, B12 concentrations, folic acid concentrations, and SLCO1B1 c.521 CC+CT polymorphism as risk factors for elevated Hcy. Multivariate logistic analysis confirmed that B12 concentrations, folic acid concentrations, and SLCO1B1 CT + CC polymorphism were significant dependent risk factors. In the sub-study, SLCO1B1 CT + CC polymorphism and male gender were identified as risk factors for Hcy, with the effect of SLCO1B1 polymorphism being more pronounced in males.Folic acid and vitamin B12 reduce Hcy concentrations, while the SLCO1B1 CT and CC polymorphisms are associated with higher Hcy levels. The impact of SLCO1B1 gene polymorphism on Hcy is notably stronger in the male population, suggesting that genetic factors play a significant role in determining Hcy levels.

    Keywords: Stroke, Homocysteine, SLCO1B1, SNP, GGT

    Received: 16 Jul 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Hu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanfang Jiang, Genetic Diagnosis Center, First Affiliated Hospital of Jilin University, Changchun, China

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