Skip to main content

CASE REPORT article

Front. Nephrol.
Sec. Clinical Research in Nephrology
Volume 4 - 2024 | doi: 10.3389/fneph.2024.1409098

A case of dipeptidyl peptidase 4 inhibitor-related kidney disease combined with renal cancer

Provisionally accepted
Yoshifumi Ubara Yoshifumi Ubara *Shigekazu Kurihara Shigekazu Kurihara Naoki Sawa Naoki Sawa Keiichi Sumida Keiichi Sumida Daisuke Ikuma¹ Daisuke Ikuma¹ Yuki Oba¹ Yuki Oba¹ Hiroki Mizuno Hiroki Mizuno Akinari Sekine Akinari Sekine Masayuki Yamanouchi Masayuki Yamanouchi Eiko Hasegawa Eiko Hasegawa Tatsuya Suwabe Tatsuya Suwabe Shinji Urakami Shinji Urakami Kei Kono Kei Kono Keiichi Kinowaki Keiichi Kinowaki Kenichi Ohashi Kenichi Ohashi Yutaka Yamaguchi Yutaka Yamaguchi
  • Toranomon Hospital, Tokyo, Japan

The final, formatted version of the article will be published soon.

    A kidney biopsy was performed in a 64-year-old woman with type 2 diabetes mellitus and less than 1 g of proteinuria who rapidly progressed to end-stage renal failure after approximately 2 years of treatment with two dipeptidyl peptidase 4 (DPP-4) inhibitors for type 2 diabetes mellitus.The biopsy revealed not only a coincidental diagnosis of renal cell carcinoma, which was not evident on pre-biopsy computed tomography, but also severe thrombotic microangiopathy (TMA)like glomerular endothelial cell damage in the noncancerous areas. These results suggest that DPP4 inhibitors may have been involved in two kidney diseases.

    Keywords: Kidney biopsy, Renal cell carcinoma, dipeptidyl peptidase(DPP) 4 inhibitors, TMA-like lesion, End-stage renal failure

    Received: 23 Apr 2024; Accepted: 24 Jun 2024.

    Copyright: © 2024 Ubara, Kurihara, Sawa, Sumida, Ikuma¹, Oba¹, Mizuno, Sekine, Yamanouchi, Hasegawa, Suwabe, Urakami, Kono, Kinowaki, Ohashi and Yamaguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yoshifumi Ubara, Toranomon Hospital, Tokyo, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.