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CASE REPORT article
Front. Nephrol.
Sec. Clinical Research in Nephrology
Volume 4 - 2024 |
doi: 10.3389/fneph.2024.1409098
A case of dipeptidyl peptidase 4 inhibitor-related kidney disease combined with renal cancer
Provisionally accepted- Toranomon Hospital, Tokyo, Japan
A kidney biopsy was performed in a 64-year-old woman with type 2 diabetes mellitus and less than 1 g of proteinuria who rapidly progressed to end-stage renal failure after approximately 2 years of treatment with two dipeptidyl peptidase 4 (DPP-4) inhibitors for type 2 diabetes mellitus.The biopsy revealed not only a coincidental diagnosis of renal cell carcinoma, which was not evident on pre-biopsy computed tomography, but also severe thrombotic microangiopathy (TMA)like glomerular endothelial cell damage in the noncancerous areas. These results suggest that DPP4 inhibitors may have been involved in two kidney diseases.
Keywords: Kidney biopsy, Renal cell carcinoma, dipeptidyl peptidase(DPP) 4 inhibitors, TMA-like lesion, End-stage renal failure
Received: 23 Apr 2024; Accepted: 24 Jun 2024.
Copyright: © 2024 Ubara, Kurihara, Sawa, Sumida, Ikuma¹, Oba¹, Mizuno, Sekine, Yamanouchi, Hasegawa, Suwabe, Urakami, Kono, Kinowaki, Ohashi and Yamaguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yoshifumi Ubara, Toranomon Hospital, Tokyo, Japan
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