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REVIEW article

Front. Nat. Prod.
Sec. Biological Activities of Natural Products
Volume 3 - 2024 | doi: 10.3389/fntpr.2024.1470639
This article is part of the Research Topic Celebrating Advances and Future Directions in Natural Products Research View all 4 articles

Boosting the Human Antiviral Response in Conjunction with Natural Plant Products

Provisionally accepted
Rashmi Srivastava Rashmi Srivastava 1Neeraj Dubey Neeraj Dubey 2Megha Sharma Megha Sharma 3Harsha Kharkwal Harsha Kharkwal 4Rajesh Bajpai Rajesh Bajpai 5*Rakesh Srivastava Rakesh Srivastava 6*
  • 1 Department of Zoology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
  • 2 Botany Department, Rashtriya PG College,, Jaunpur, India
  • 3 Department of Botany, University of Delhi,, Delhi, India
  • 4 Amity Institute of Phytochemistry and Phytomedicine, Amity University, Noida, India
  • 5 Department of Environmental Studies, North Eastern Hill University, Shillong, India
  • 6 Research and Development, Helix Bioscience,, New Delhi, India

The final, formatted version of the article will be published soon.

    The increasing prevalence of viral infections and the emergence of drug-resistant or mutant strains necessitate the exploration of novel antiviral strategies. Accumulating evidence suggests that natural plant products have significant potential to enhance the human antiviral response. Various plant natural products (PNPs) known for their antiviral properties have been evaluated for their ability to modulate immune responses and inhibit viral infections. Research has focused on understanding the mechanisms by which these PNPs interact with the human immune system and their potential to complement existing antiviral therapies. PNPs control compounds such as alkaloids, flavonoids, terpenoids, and polyphenols to promote antiviral cytokine synthesis, increase T-cell and macrophage activity, and activate antiviral genes.Studies have investigated the molecular interactions between PNPs, viruses, and host cells, exploring the potential of combining PNPs with conventional antiviral drugs to enhance efficacy. However, several challenges remain, including identifying, characterizing, and standardizing PNP extracts, optimizing dosages, improving bioavailability, assessing longterm safety, and navigating regulatory approval. The promising potential of PNPs is being explored to develop new, effective, and natural antiviral therapies. This review outlines a framework for an integrative approach to connect the full potential of PNPs in combating viral infections and improving human health. By combining natural plant products with conventional antiviral treatments, more effective and sustainable management of viral diseases can be achieved.

    Keywords: Secondary metabolite, human pathogen, virus, antiviral response, Immunity, Plants

    Received: 25 Jul 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Srivastava, Dubey, Sharma, Kharkwal, Bajpai and Srivastava. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rajesh Bajpai, Department of Environmental Studies, North Eastern Hill University, Shillong, India
    Rakesh Srivastava, Research and Development, Helix Bioscience,, New Delhi, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.