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REVIEW article

Front. Nat. Prod.
Sec. Biological Activities of Natural Products
Volume 3 - 2024 | doi: 10.3389/fntpr.2024.1452797
This article is part of the Research Topic Natural Products in Medicine: Insights from History and Ethnopharmacology View all 11 articles

Clerodendranthus spicatus: a comprehensive review of the chemical constituents, pharmacology, quality control and clinical applications

Provisionally accepted
Lu Liu Lu Liu 1*Xingmeng Jiao Xingmeng Jiao 1Qiong Jin Qiong Jin 1Peifeng Zhu Peifeng Zhu 1Zhuomin Tan Zhuomin Tan 2Yanqing Xie Yanqing Xie 1
  • 1 Yunnan Yunzhong Institute of Nutrition and Health，Yunnan University of Chinese Medicine, Kunming, China
  • 2 Kunming Medical University, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    30 Clerodendranthus spicatus (CS), is an herbaceous perennial belonging to the family 31 Lamiaceae. The herb is extensively employed in traditional Chinese medicine for the 32 mitigation of nephritis, cystitis, kidney stones, urological tract stones, gout, and other 33 urinary conditions. Numerous research studies have been conducted in the past to 34 explore the traditional medicinal value, phytochemical composition, pharmacological 35 effects, and quality control measures associated with this plant. This has motivated us 36 to systematically search various online databases such as Google Scholar, PubMed, 37 Science Direct, Elsevier, CNKI, and Sci-Hub using specific keywords to get the most 38 recent research information findings related to this plant. Phytochemical investigations 39 have identified that this plant predominantly contains flavonoids, terpenoids, 40 phenylpropanoids, and volatile oil compounds. Certain constituents have been 41 employed as markers in quality assessment research, and some were recognized as 42 bioactive agents in the management of specific ailments. These components have 43 demonstrated notable effectiveness in combating bacterial infections, reducing 44 inflammation, providing antioxidant properties, managing hyperuricemia, and offering 45 renal protection. Notably, clinical trials have confirmed its remarkable efficacy in 46 treating urinary inflammation and stones. We acquired recent research findings 47 concerning CS in the fields of phytochemistry, pharmacology, quality control, and 48 clinical applications via online search. These findings have been summarized and 49 analysed to offer a valuable reference for further comprehensive research, development, 50 and utilization of CS.

    Keywords: Clerodendranthus spicatus, Chemical constituents, Pharmacology, Quality control, clinical application

    Received: 21 Jun 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Liu, Jiao, Jin, Zhu, Tan and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lu Liu, Yunnan Yunzhong Institute of Nutrition and Health，Yunnan University of Chinese Medicine, Kunming, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.