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ORIGINAL RESEARCH article

Front. Nat. Prod.
Sec. Biological Activities of Natural Products
Volume 3 - 2024 | doi: 10.3389/fntpr.2024.1394657
This article is part of the Research Topic Natural Products in Medicine: Insights from History and Ethnopharmacology View all 6 articles

Rosmarinus officinalis Essential Oil Triggers Depression Followed by

Provisionally accepted
Daniella B. de Araújo Daniella B. de Araújo *
  • Federal University of Pará, Belém, Brazil

The final, formatted version of the article will be published soon.

    Rosemary essential oil (Rosmarinus officinales) is widely used in folk medicine 10. and has proven therapeutic effects. Our research evaluated high doses of Rosemary 11. essential oil in Wistar rats. Fifty-four male rats between 180 and 200g were used. The 12. present article was divided into three experiments: (1) Behavioral monitoring of the 13. animals after administration of 500 mg/kg i.p., (2) Electrocorticographic records 14. after drug administration and (3) Anticonvulsant drug reaction, where were applied 15. Phenytoin, Phenobarbital and Diazepam 10 mg/kg i.p. The results showed that the application 16. of rosemary oil, presented two phases. Phase 1 was characterized by the appearance of 17. myorelaxation and a reduction in the power of the electrocorticogram in low-frequency 18. cerebral oscillations. Phase 2 was characterized by increased excitability, with the 19. appearance of convulsions and increased power of electrocorticographic recordings in cerebral 20. oscillations up to 40 Hz. In this phase, three tracing patterns were observed. Beta 21. oscillations were the most prevalent and were better controlled by Diazepam, which 22. demonstrates that the excitatory activity of Rosmarinus officinalis essential oil is related to 23. the reduction of GABAergic activity.

    Keywords: Ethnopharmacology, Electrocorticographic record, Behavioral 7. Characterization, Rosemary essential oil, Rosmarinus officinalis

    Received: 01 Mar 2024; Accepted: 16 May 2024.

    Copyright: © 2024 de Araújo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Daniella B. de Araújo, Federal University of Pará, Belém, Brazil

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