AUTHOR=de Oliveira Celso R. , Ledvina Zachary D. , Leonard Michael D. , Odoh Samuel O. , Dodson Craig D. , Jeffrey Christopher S. 

TITLE=Isolation of new neolignans and an unusual meroterpenoid from Piper cabagranum

JOURNAL=Frontiers in Natural Products

VOLUME=2

YEAR=2024

URL=https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2023.1332436

DOI=10.3389/fntpr.2023.1332436

ISSN=2813-2602

ABSTRACT=<p>A novel meroterpenoid cabagranin D was isolated with related neolignans cabagranins A–C from the leaves of <italic>Piper cabagranum</italic> (Costa Rica). Cabagranins A–C represent the first examples of 3,3′-neolignans isolated from the plant genus <italic>Piper</italic>, and the meroterpenoid cabagranin D displays an unprecedented Diels–Alder conjugate of an unsubstituted phenylpropenone and α-phellandrene. Details of the full structural elucidation of these compounds and a discussion of their potential biosynthetic relationships are presented.</p>