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REVIEW article

Front. Nanotechnol.
Sec. Nanomaterials
Volume 6 - 2024 | doi: 10.3389/fnano.2024.1513683
This article is part of the Research Topic Nanomaterial and Nanostructures for Cancer and Pathogenic Infection Diagnosis and Therapy View all 6 articles

Integrating engineered nanomaterials with extracellular vesicles: Advancing targeted drug delivery and biomedical applications

Provisionally accepted
Hai Jiang Hai Jiang 1Ranil Vikraman Kumarasamy Ranil Vikraman Kumarasamy 2Jinjin Pei Jinjin Pei 1Kamaraj Raju Kamaraj Raju 3GOPALAKRISHNAN VELLIYUR KANNIAPPAN GOPALAKRISHNAN VELLIYUR KANNIAPPAN 4Chella Perumal Palanisamy Chella Perumal Palanisamy 5*
  • 1 Shaanxi University of Technology, Hanzhong, Shaanxi, China
  • 2 Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
  • 3 Rathinam College of Arts and Science, Coimbatore, Tamil Nadu, India
  • 4 Department of Biotechnology, Saveetha School of Engineering, Saveetha University, Chennai, Tamilnadu, India
  • 5 Chulalongkorn University, Bangkok, Bangkok, Thailand

The final, formatted version of the article will be published soon.

    Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs and nanoparticles. This comprehensive review explores the integration of engineered nanomaterials with EVs to advance drug delivery systems. It covers various aspects of this integration, including techniques for synthesizing, loading, characterizing, and applying nanomaterials within EVs. Methodologies for integrating diverse nanocarriers like nanoparticles, liposomes, and quantum dots into EVs are discussed, along with characterization methods such as electron microscopy and light scattering. Attention is also given to considerations of biological compatibility, safety assessments, and strategies for surface modification to enhance targeting precision. Highlighting various applications, including targeted drug delivery, cancer therapy, and vaccine development, the review underscores the potential of EV-nanomaterial hybrids to leverage EVs' innate targeting capabilities and the versatility of nanomaterials. However, it also addresses challenges such as scalability, standardization, and safety that must be overcome to facilitate the clinical translation of these promising biomedical solutions.

    Keywords: engineered nanomaterials, extracellular vesicles, characterization, Targeted Drug Delivery, biomedical applications

    Received: 18 Oct 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Jiang, Kumarasamy, Pei, Raju, VELLIYUR KANNIAPPAN and Palanisamy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chella Perumal Palanisamy, Chulalongkorn University, Bangkok, 10330, Bangkok, Thailand

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.