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REVIEW article

Front. Nanotechnol.
Sec. Biomedical Nanotechnology
Volume 6 - 2024 | doi: 10.3389/fnano.2024.1490980

Plant-Mediated Gold Nanoparticles in Cancer Therapy: Exploring Anti-Cancer Mechanisms, Drug Delivery Applications, and Future Prospects

Provisionally accepted
Nisha Yadav Nisha Yadav 1*Rohan Sachan Rohan Sachan 2Anjuvan Singh Anjuvan Singh 1*Arun Karnwal Arun Karnwal 1*Amrullah Shidiki Amrullah Shidiki 3*Gaurav Kumar Gaurav Kumar 1*
  • 1 Lovely Professional University, Phagwara, Punjab, India
  • 2 GNA University, Phagwara, Punjab, India
  • 3 National Medical College, Birgunj, Nepal

The final, formatted version of the article will be published soon.

    Gold nanoparticles (AuNPs) exhibit great promise in cancer therapy and drug delivery due to their unique physicochemical properties. The utilization of plant extracts and phytochemicals for the synthesis of AuNPs offers a simple, rapid, eco-friendly, and cost-effective alternative. This review provides an in-depth analysis of the role of plant-mediated AuNPs in cancer treatment, focusing on their core mechanisms, drug delivery applications, and future potential. It emphasizes the advantages of green synthesis methods for cancer therapy, detailing the processes involved and highlighting various plants used for nanoparticle biosynthesis. The review also explores the anti-cancer effects of plant-mediated AuNPs, such as their ability to selectively target cancer cells and induce apoptosis, supported by both in vitro and in vivo studies. Additionally, the application of these nanoparticles in targeted drug delivery for cancer therapy is examined. The review addresses biocompatibility and toxicity concerns, providing insights into the safety of these nanoparticles. Future research directions and challenges are discussed to overcome current limitations and maximize their clinical applicability.In summary, plant-mediated AuNPs offer a sustainable and effective approach for cancer therapy and drug delivery, with their green synthesis and diverse anti-cancer properties highlighting their potential.Further research is essential to fully realize their clinical benefits.

    Keywords: gold nanoparticles, Plant mediated, mechanism of action, anticancer, Drug delivery, Toxicity

    Received: 06 Sep 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Yadav, Sachan, Singh, Karnwal, Shidiki and Kumar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Nisha Yadav, Lovely Professional University, Phagwara, 144411, Punjab, India
    Anjuvan Singh, Lovely Professional University, Phagwara, 144411, Punjab, India
    Arun Karnwal, Lovely Professional University, Phagwara, 144411, Punjab, India
    Amrullah Shidiki, National Medical College, Birgunj, Nepal
    Gaurav Kumar, Lovely Professional University, Phagwara, 144411, Punjab, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.