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REVIEW article

Front. Nanotechnol.
Sec. Nanomaterials
Volume 6 - 2024 | doi: 10.3389/fnano.2024.1479993
This article is part of the Research Topic Nanomaterial and Nanostructures for Cancer and Pathogenic Infection Diagnosis and Therapy View all 5 articles

Clinical Applications and Therapeutic Potentials of Advanced Nanoparticles: A Comprehensive Review on Completed Human Clinical Trials

Provisionally accepted
Ranil V. Kumarasamy Ranil V. Kumarasamy 1Prabhu Natarajan Prabhu Natarajan 2Dr Vidhya Rekha Umapathy Dr Vidhya Rekha Umapathy 3Jeane R. Roy Jeane R. Roy 4Safia O. Rab Safia O. Rab 5Mohd Saeed Mohd Saeed 6Mani Panagal Mani Panagal 7Monica Mironescu Monica Mironescu 8Guru P. Srinivasan Guru P. Srinivasan 9Chella Perumal Palanisamy Chella Perumal Palanisamy 10*
  • 1 Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
  • 2 Ajman University, Ajman, Ajman, United Arab Emirates
  • 3 Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India
  • 4 Bharath Institute of Science and Technology, Chennai, Tamil Nadu, India
  • 5 King Khalid University, Abha, Saudi Arabia
  • 6 University of Hail, Ha'il, Hail, Saudi Arabia
  • 7 Annai College of Arts and Science, Kumbakonam, India
  • 8 Lucian Blaga University of Sibiu, Sibiu, Sibiu, Romania
  • 9 Center for Global Health Research, Saveetha Medical College & Hospital, Chennai, Tamil Nadu, India
  • 10 Chulalongkorn University, Bangkok, Bangkok, Thailand

The final, formatted version of the article will be published soon.

    Nanoparticles have become known asare attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the therapeutic potentials of cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches of major scientific databases, relevant studies published up to March 2024 were included, focusing on clinical trials utilizing advanced nanoparticles for therapeutic purposes. The review comprehensively discusses the diverse applications of nanoparticles in oncology, infectious diseases, neurology, and other medical fields. Additionally, it scrutinizes the safety profiles, efficacy outcomes, and challenges associated with nanoparticle-based therapies. The findings underscore significant progress in translating nanoparticle research into clinical practice and highlight the potential of these innovative platforms to revolutionize medical treatments. This review contributes valuable insights into the growing field of nanoparticle-based therapeutics, fostering a deeper understanding of their clinical applications and implications for in medical practice.

    Keywords: Nanoparticles, Nanomedicine, clinical trials, Drug delivery, Targeted therapy Font: (Default) Times New Roman, 12 pt Formatted: Font: Not Italic Formatted: Font: (Default) Times New Roman, 12 pt

    Received: 13 Aug 2024; Accepted: 20 Sep 2024.

    Copyright: © 2024 Kumarasamy, Natarajan, Umapathy, Roy, Rab, Saeed, Panagal, Mironescu, Srinivasan and Palanisamy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chella Perumal Palanisamy, Chulalongkorn University, Bangkok, 10330, Bangkok, Thailand

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.