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REVIEW article

Front. Nanotechnol.
Sec. Biomedical Nanotechnology
Volume 6 - 2024 | doi: 10.3389/fnano.2024.1424562

Animal-Based Evidence Supports Protective Activity of Bioengineered Silver and Gold Nanomaterials on Hepatic and Renal Function Profile Parameters

Provisionally accepted
Hamed Barabadi Hamed Barabadi 1*Hesam Noqani Hesam Noqani 1Maha Soltani Maha Soltani 1Ayeh Sabbagh Kashani Ayeh Sabbagh Kashani 2
  • 1 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 2 Faculty of Pharmacy, Islamic Azad University of Medical Sciences, Tehran, Iran

The final, formatted version of the article will be published soon.

    The liver and kidneys are vital organs responsible for essential metabolic and excretory functions, and their protection is a cornerstone of therapeutic innovation. This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective agents for liver and kidney health, based on evidence from animal studies. The discussion emphasizes green synthesis approaches, which offer sustainable and biocompatible routes for nanoparticle production. Key findings reveal the effects of these nanoparticles (NPs) on hepatic enzymes—Aspartate aminotransferase (AST), Alanine transaminase (ALT), and Alkaline phosphatase (ALP)—and renal function markers, including urea and creatinine levels, under both healthy and pathological conditions. In diseased animal models, biosynthesized NPs significantly reduced ALT, AST, ALP, urea, and creatinine levels, demonstrating their protective effects. Conversely, in healthy animals, lower nanoparticle concentrations exhibited no statistically significant impact on these parameters, suggesting their safety at therapeutic doses. This review presents the novelty of bioengineered NPs as potential therapeutic agents for hepatic and renal protection while highlighting the need for further research into their pharmacokinetics and pharmacodynamics to advance clinical translation.

    Keywords: silver nanoparticles, gold nanoparticles, Biological synthesis, Liver protection, kidney protection

    Received: 28 Apr 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Barabadi, Noqani, Soltani and Sabbagh Kashani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hamed Barabadi, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.