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MINI REVIEW article

Front. Nanotechnol.
Sec. Nanomaterials
Volume 6 - 2024 | doi: 10.3389/fnano.2024.1403313
This article is part of the Research Topic Nanomaterial and Nanostructures for Cancer and Pathogenic Infection Diagnosis and Therapy View all articles

Inhalable Dry Powder Nano-Formulations: Advancing Lung Disease Therapy-A Review

Provisionally accepted
Faiza Naureen Faiza Naureen 1Maqsood Ur Rehman Maqsood Ur Rehman 2*Yasar Shah Yasar Shah 1Abdullah Khan Abdullah Khan 2Muhammad Shafique Muhammad Shafique 3*Jahangir Khan Jahangir Khan 2Basheer Ahmed Basheer Ahmed 4Kifayat Ullah Shah Kifayat Ullah Shah 5
  • 1 Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Khyber Pakhtunkhwa, Pakistan
  • 2 Department of Pharmacy, University of Malakand, Chakdara Dir, Pakistan
  • 3 Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Al-Dawadmi, Saudi Arabia
  • 4 Department of Zoology, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan
  • 5 Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan

The final, formatted version of the article will be published soon.

    Human exposure to various respiratory diseases has sparked an interest among scientists to propose and promote inhalable nanoparticle-based products.This new drug delivery system will be an effective and prompt therapy for next-generation respiratory therapeutics.There are many formulations to treat lung diseases,i.e.,oral, injectable, aerosol, nebulizer-based, etc. But,due to extended distribution and elimination, repeated intake, and complex systems of application,these treatments create overload on patients along with other expenses of daily life.Amid these treatments, inhalable nanoparticlebased dry powder formulations are considered superior owing to their simplicity,convenience of use,and long-term stability.This review aims to formulate an inhalable nanoparticle dry powder formulation to attain confined distribution of the remedy to the respiratory system.Dry powder formulations based on inhalable nanoparticles provide a novel and cutting-edge method of treating lung conditions.This novel drug delivery system is an improved treatment for lung disorders in terms of its efficacy and reduced dose requirement. Subsequently,the availability of this formulation will be an alternative option for patients to improve treatment compliance and,foremost, therapeutic outcomes in different lung ailments.The salient features of dry formulations that illustrate their uniqueness are deep penetration to lung tissues, enhanced deposition in lung regions, improved solubility, elevated bioavailability, targeted drug delivery, stability at storage, convenient to use,versatile and customizable formulation.This novel inhalable formulation is based on finely dried nanoparticles or freeze-dried particles. This formulation will contain an excessive amount of dried nanoparticles, and if it is combined with a beneficial tool, i.e.,a spray/pump/puffer, it will be a pleasant way to apply drugs directly to the lungs.

    Keywords: Inhalation, dry-powder Nano formulation, Lung Diseases, Nano medicine, bioavailability

    Received: 19 Mar 2024; Accepted: 10 Jun 2024.

    Copyright: © 2024 Naureen, Rehman, Shah, Khan, Shafique, Khan, Ahmed and Shah. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Maqsood Ur Rehman, Department of Pharmacy, University of Malakand, Chakdara Dir, Pakistan
    Muhammad Shafique, Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Al-Dawadmi, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.