AUTHOR=Zhang Bingjie , Deng Chunshan , Cai Chunzhi , Li Xiaojian TITLE=In Vivo Neural Interfaces—From Small- to Large-Scale Recording JOURNAL=Frontiers in Nanotechnology VOLUME=4 YEAR=2022 URL=https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2022.885411 DOI=10.3389/fnano.2022.885411 ISSN=2673-3013 ABSTRACT=

Brain functions arise from the coordinated activation of neuronal assemblies distributed across multiple brain regions. The electrical potential from the neuron captured by the electrode can be processed to extract brain information. A large number of densely and simultaneously recorded neuronal potential signals from neurons spanning multiple brain regions contribute to the insight of specific behaviors encoded by the neural ensembles. In this review, we focused on the neural interfaces developed for small- to large-scale recordings and discussed the developmental challenges and strategies in microsystem, electrode device, and interface material levels for the future larger-scale neural ensemble recordings.