AUTHOR=Brar Basanti , Ranjan Koushlesh , Palria Ankur , Kumar Rajesh , Ghosh Mayukh , Sihag Sweety , Minakshi Prasad 

TITLE=Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

JOURNAL=Frontiers in Nanotechnology

VOLUME=Volume 3 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2021.699266

DOI=10.3389/fnano.2021.699266

ISSN=2673-3013

ABSTRACT=Colorectal cancer (CRC) is the third most frequently occurring tumor in the human population. CRCs are usually adenocarcinomatous and originate as a polyp on the inner wall of the colon or rectum which may become malignant in the due course of time. Although the therapeutic options of CRC are limited, the early diagnosis of CRC may play an important role in preventive and therapeutic interventions to decrease the mortality rate. The CRC-affected tissues exhibit several molecular markers which may be exploited as the novel strategy to develop newer approaches for the treatment of the disease. Nanotechnology consists of a wide array of innovative and astonishing nanomaterials with both diagnostics as well as therapeutic potential. Several nanomaterials and nanoformulations such as Carbon nanotubes, Dendrimer, Liposomes, Silica Nanoparticles, Gold nanoparticles,Metal-organic frameworks, Core-shell polymeric nano-formulations, Nano-emulsion System, etc can be used to targeted anti-cancer drug delivery and diagnostic purposes in CRC. The light-sensitive photosensitizer drugs loaded gold and silica nanoparticles can be used to diagnose as well as the killing of CRC cells by thetargeted delivery of anti-cancer drugs to cancer cells.This review is focused on the recent advancement of nanotechnology in the diagnosis and treatment of CRC.