AUTHOR=Preeti , Radhakrishnan V. S. , Mukherjee Sushanto , Mukherjee Sujata , Singh Surinder P. , Prasad Tulika TITLE=ZnO Quantum Dots: Broad Spectrum Microbicidal Agent Against Multidrug Resistant Pathogens E. coli and C. albicans JOURNAL=Frontiers in Nanotechnology VOLUME=2 YEAR=2020 URL=https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2020.576342 DOI=10.3389/fnano.2020.576342 ISSN=2673-3013 ABSTRACT=

Infectious microbial diseases are leading causes of morbidity and mortality worldwide. Further, emergence of Multidrug resistance (MDR) in microbes has posed a critical concern for public healthcare and microbial therapeutics. Nano-based drug compositions might be ideal candidates to address the challenges of microbial drug resistance. Herein, we synthesized monodispersed, spherical ZnO quantum dots (QDs) of average diameter 5–6 nm as biosafe, nanomicrobicidal agent against MDR pathogens. The broad spectrum microbicidal potential of ZnO QDs was evaluated against Extended Spectrum Beta Lactamase (ESBL) producing MDR isolates of E. coli (from UTI patients with resistance to antibiotics of different classes viz. third & fourth generation of cephalosporin, penicillin, monobactams, and quinolones) and MDR isolates of C. albicans (from three different AIDS patients who during therapy acquired drug resistance and sensitive isolates evolved into MDR strains). ZnO QDs exhibited dose dependent, broad spectrum microbicidal activity against all MDR isolates of E. coli and C. albicans. Highly reduced growth indicating highly reduced cell viability was observed in all MDR isolates of E. coli and C. albicans at minimum inhibitory concentration (MIC) of 200 μg/ ml ZnO QDs and the growth/ cell viability was further reduced in presence of 250 and 400 μg/ ml of ZnO QDs for E. coli and C. albicans, respectively. To the best of our knowledge, microbicidal potential of ZnO QDs against microbial strains exhibiting MDR for currently used drugs has not been studied. Results of present study indicate that ZnO QDs might be promising as next generation broad spectrum alternative for combating MDR in microbial pathogens.