AUTHOR=Eichler Sabrina A., Meier Jochen C.

TITLE=E-I balance and human diseases - from molecules to networking

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=1

YEAR=2008

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/neuro.02.002.2008

DOI=10.3389/neuro.02.002.2008

ISSN=1662-5099

ABSTRACT=<p>Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (<abbrev>E-I</abbrev>) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.</p>