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BRIEF RESEARCH REPORT article
Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1576941
Transcriptomic Analysis of the TRP Gene Family in Human Brain Physiopathology
Provisionally accepted
Barbara Małgorzata Olejniczak 1,2
Arpita Balakrishnan 2,3
Justyna Augustyniak 4
Elzbieta Salińska 4
Agnieszka Bronisz 3
Jakub Godlewski 1*- 1 Department of Neurooncology, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland
- 2 Translational Medicine Doctoral School, Centre of Postgraduate Medical Education, Warsaw, Masovian, Poland
- 3 Tumor Microenvironment Laboratory, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland
- 4 Department of Neurochemistry, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland
The transient receptor potential (TRP) gene family is vital to cellular physiology, mediating ion flow across membranes and facilitating sensory signal transduction. This article examines the transcriptomic landscape of TRP genes, emphasizing their varying expression across organs, tissues, and cells, with a particular focus on the brain. Analysis reveals a distinct spatial distribution of TRP gene expression, notably enriched in the hippocampus during brain development, highlighting their essential role in neuronal function. Utilizing datasets from the Human Protein Atlas, Allen Human Brain Atlas, and studies on aging and dementia, associations are identified between TRP gene expression and the development or pathophysiology of neural tissue, highlighting the therapeutic potential of TRP channels in addressing, e.g., sensory impairments and cognitive decline. These insights into the regulatory dynamics of TRP channels lay a foundation for developing targeted interventions for neurodegenerative disorders.
Keywords: Transient receptor potential (TRP), Brain Physiopathology, Transcriptomic Analysis, Dementia, Neuroscience
Received: 28 Feb 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Olejniczak, Balakrishnan, Augustyniak, Salińska, Bronisz and Godlewski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jakub Godlewski, Department of Neurooncology, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.