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MINI REVIEW article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1536577
This article is part of the Research Topic G Protein-Coupled Receptors in the Control of Energy Homeostasis and Food Intake View all articles

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism

Provisionally accepted
Ou Fu Ou Fu *Tian Qiu Tian Qiu
  • Jiangnan University, Wuxi, China

The final, formatted version of the article will be published soon.

    G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and metabolism, with a focus on emerging cell-type-specific investigations. These studies reveal that diverse GPCR-expressing neuronal populations are intricately linked to feeding and energy balance. We also discuss recent findings that highlight the interaction of distinct peptide-GPCR systems in modulating complex feeding behaviors.

    Keywords: hypothalamus1, GPCR (G protein coupled receptor) 2, GLP-1 receptor3, Melanocortin receptor4, NPY receptor5, food intake6, Metabolism7

    Received: 29 Nov 2024; Accepted: 24 Jan 2025.

    Copyright: © 2025 Fu and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ou Fu, Jiangnan University, Wuxi, China

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