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MINI REVIEW article
Front. Mol. Neurosci.
Sec. Brain Disease Mechanisms
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1507575
This article is part of the Research Topic The RNA World: Non-Coding RNAs and Innovative Therapies in Neurological Disorders - Volume II View all 4 articles
Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases
Provisionally accepted
Mandana AmeliMojarad *
Melika Amelimojarad - National Institute for Genetic Engineering and Biotechnology (Iran), Tehran, Tehran, Iran
Recent advancements in sequencing technology have allowed scientists to study the function and expression of different non-coding RNAs (ncRNAs). Circular RNAs (circRNAs) are increasingly recognized as prognostic and diagnostic biomarkers. These classes of ncRNAs are closed loops that are made from alternative mRNA splicing and can be found in large quantities with their evolutionarily conserved features across different species. These circRNAs can be derived from both coding and non-coding transcript and regulate cellular proteins and the expression of linear mRNA transcripts via their ability to act as miRNA sponges at various levels. Different circRNAs can affect the neurodegenerative disease pathogenesis such as Alzheimer's disease (AD), via altering a variety of methods. However, there is still limited knowledge about circRNAs in brain cells. Therefore, in this review, we will focus on the role of circRNAs in the brain to reveal a new potential therapeutic target and open the door to novel therapies and improved management of brain and neurodegenerative diseases.
Keywords: Alzheimer's disease, biomarkers, CircRNAs, non-coding RNA, Neurological Disease
Received: 08 Oct 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 AmeliMojarad and Amelimojarad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mandana AmeliMojarad, National Institute for Genetic Engineering and Biotechnology (Iran), Tehran, Tehran, Iran
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