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REVIEW article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1482015
This article is part of the Research Topic Mechanisms of Ferroptosis, Necroptosis, and Pyroptosis in Neurological Disorders, Brain Injuries, and Brain-Related Diseases View all articles

Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke

Provisionally accepted
Heyan Tian Heyan Tian 1*Zhigang Mei Zhigang Mei 2*Chen Xu Chen Xu 1*Jinwen Ge Jinwen Ge 2,3*Yunxing Lei Yunxing Lei 1*Jingtao Zhou Jingtao Zhou 1*Longjun Liu Longjun Liu 1*Tong Yang Tong Yang 2Yue Zhou Yue Zhou 2*
  • 1 Shenzhen Polytechnic University, shenzhen, China
  • 2 Hunan University of Chinese Medicine, Changsha, Anhui Province, China
  • 3 Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Anhui Province, China

The final, formatted version of the article will be published soon.

    PANoptosis is a novelly defined mode of programmed cell death that involves the activation of multiple cellular death pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy is a crucial cellular process that maintains cellular homeostasis and protects cells from various stresses. PANoptosis and autophagy, both vital players in the intricate pathological progression of ischemic stroke (IS), a brain ailment governed by intricate cell death cascades, have garnered attention in recent years for their potential interplay. While mounting evidence hints at a crosstalk between these two processes in IS, the underlying mechanisms remain elusive. Therefore, this review delves into and dissects the intricate mechanisms that underpin the intersection of PANoptosis and autophagy in this devastating condition. In conclusion, the crosstalk between PANoptosis and autophagy in IS presents a promising target for the development of novel stroke therapies. Understanding the interplay between these two pathways offers a much-needed insight into the underlying mechanisms of IS and opens the possibility for new therapeutic strategies.

    Keywords: ischemic stroke, PANoptosis, Autophagy, pyroptosis, Apoptosis, necroptosis, Therapeutics

    Received: 17 Aug 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Tian, Mei, Xu, Ge, Lei, Zhou, Liu, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Heyan Tian, Shenzhen Polytechnic University, shenzhen, China
    Zhigang Mei, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
    Chen Xu, Shenzhen Polytechnic University, shenzhen, China
    Jinwen Ge, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
    Yunxing Lei, Shenzhen Polytechnic University, shenzhen, China
    Jingtao Zhou, Shenzhen Polytechnic University, shenzhen, China
    Longjun Liu, Shenzhen Polytechnic University, shenzhen, China
    Yue Zhou, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.