Skip to main content

ORIGINAL RESEARCH article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1459358

Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevoflurane

Provisionally accepted
Yanhong Wang Yanhong Wang 1Yun Chen Yun Chen 2Mengxiao Zhang Mengxiao Zhang 2Chengdong Yuan Chengdong Yuan 1Yu Zhang Yu Zhang 3Xingjian Liu Xingjian Liu 4Yi Zhang Yi Zhang 1*Xiaoli Liang Xiaoli Liang 3
  • 1 Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China
  • 2 Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, Guizhou Province, China
  • 3 Zunyi Medical University, Zunyi, Guizhou Province, China
  • 4 Xishui County People's Hospital, Huanggang, China

The final, formatted version of the article will be published soon.

    Introduction: Whether repeated inhalation of sevoflurane during the neonatal period causes long-term learning and memory impairments in humans is unclear. Some recent investigations have indicated that general anesthesia drugs affect histone methylation modification and may further affect learning and memory ability.This study aimed to explore the role and mechanism of histone methylation in long-term cognitive dysfunction caused by repeated inhalation of sevoflurane during the neonatal period. Methods: Neonatal SD rats were assigned into three groups. Sevoflurane group and sevoflurane +AS8351 group were exposed to 2% sevoflurane for 4 hours on postnatal day 7 (P7), day 14 (P7) and day 21 (P21), and the control group was inhaled the air oxygen mixture at the same time.From postnatal day 22 to 36, rats in the +AS8351 group were treated with AS8351 while those in the Sevoflurane group and control group were treated with normal saline.Half of the rats were carried out Y-maze, Morris water maze (MWM), western blot and transmission electron microscope at P37,and the remaining rats were fed to P97 for the same experiment. Results: Neonatal sevoflurane exposure affected histone demethylase expression in hippocampus, changed histone methylation levels, Down-regulated synapse-associated protein expression, impaired synaptic plasticity and long-term cognitive dysfunction. and KDM5B inhibitors partially restored the negative reaction caused by sevoflurane exposure. Discussion: In conclusion, KDM5B inhibitor can save the long-term learning and memory impairment caused by sevoflurane exposure in neonatal period by inhibiting KDM5B activity.

    Keywords: sevoflurane, cognitive, Histone Methylation, Hippocampus, neonatal

    Received: 04 Jul 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Wang, Chen, Zhang, Yuan, Zhang, Liu, Zhang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Zhang, Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.