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REVIEW article

Front. Mol. Neurosci.
Sec. Brain Disease Mechanisms
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1459083

Functions of TRPs in retinal tissue in physiological and pathological conditions

Provisionally accepted
Thaianne H. Oliveira do Nascimento Thaianne H. Oliveira do Nascimento 1Danniel Pereira-Figueiredo Danniel Pereira-Figueiredo 1Louise Veronoze Resende Louise Veronoze Resende 1Amanda Alves Nascimento Amanda Alves Nascimento 1Francesco De Logu Francesco De Logu 2Romina Nassini Romina Nassini 2Paula Campello-Costa Paula Campello-Costa 1Adriana Melibeu-Faria Adriana Melibeu-Faria 1Daniel Souza Monteiro de Araújo Daniel Souza Monteiro de Araújo 2*Karin Da C. Calaza Karin Da C. Calaza 1
  • 1 Fluminense Federal University, Niterói, Rio de Janeiro, Brazil
  • 2 University of Florence, Florence, Tuscany, Italy

The final, formatted version of the article will be published soon.

    The Transient Receptor Potential (TRP) constitutes a family of channels subdivided into seven subfamilies: Ankyrin (TRPA), Canonical (TRPC), Melastatin (TRPM), Mucolipin (TRPML), NOmechano-potential C (TRPN), Polycystic (TRPP) and Vanilloid (TRPV). Although they are structurally similar to one another, the peculiarities of each subfamily are key to the response to stimuli and the signaling pathway that each one triggers. TRPs are non-selective cation channels, most of which are permeable to Ca 2+ , which is a well-established second messenger that modulates several intracellular signaling pathways and is involved in physiological and pathological conditions in various cell types. TRPs depolarize excitable cells by increasing the influx of Ca 2+ , Na + , and other cations. Most TRP families are activated by temperature variations, membrane stretching, or chemical agents and, therefore, are defined as polymodal channels. All TPRs are expressed, at some level, in the central nervous system (CNS) and ocular-related structures, such as the retina and optic nerve (ON), except the TRPP in the ON. TRPC, TRPM, TRPV, and TRPML are found in the retinal pigmented cells, whereas only TRPA1 and TRPM are detected in the uvea. Accordingly, several studies have focused on the search to unravel the role of TRPs in physiological and pathological conditions related to the eyes. Thus, this review aims to shed light on endogenous and exogenous modulators, triggered cell signaling pathways, and localization and roles of each subfamily of TRP channels in physiological and pathological conditions in the retina, optic nerve, and retinal pigmented epithelium of vertebrates.

    Keywords: age-related macular degeneration, Glaucoma, Retinitis Pigmentosa, Diabetic Retinopathy, TRPs channels

    Received: 03 Jul 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Oliveira do Nascimento, Pereira-Figueiredo, Veronoze Resende, Alves Nascimento, De Logu, Nassini, Campello-Costa, Melibeu-Faria, Souza Monteiro de Araújo and Calaza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Daniel Souza Monteiro de Araújo, University of Florence, Florence, 50121, Tuscany, Italy

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