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REVIEW article
Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 |
doi: 10.3389/fnmol.2024.1427054
This article is part of the Research Topic Nervous Regeneration and Functional Recovery in the Central and Peripheral Nervous Systems: Diagnostic Methods, Gene/Cell therapies, and Interventions View all articles
Wnt Signaling Pathway in Spinal Cord Injury: From Mechanisms to Potential Applications
Provisionally accepted- Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
Spinal cord injury (SCI) denotes damage to both the structure and function of the spinal cord, primarily manifesting as sensory and motor deficits caused by disruptions in neural transmission pathways, potentially culminating in irreversible paralysis. Its pathophysiological processes are complex, with numerous molecules and signaling pathways intricately involved. Notably, the pronounced upregulation of the Wnt signaling pathway post-SCI holds promise for neural regeneration and repair.Activation of the Wnt pathway plays a crucial role in neuronal differentiation, axonal regeneration, local neuroinflammatory responses, and cell apoptosis, highlighting its potential as a therapeutic target for treating SCI. However, excessive activation of the Wnt pathway can also lead to negative effects, highlighting the need for further investigation into its applicability and significance in SCI. This paper provides an overview of the latest research advancements in the Wnt signaling pathway in SCI, summarizing the recent progress in treatment strategies associated with the Wnt pathway and analyzing their advantages and disadvantages. Additionally, we offer insights into the clinical application of the Wnt signaling pathway in SCI, along with prospective avenues for future research direction.
Keywords: spinal cord injury, Wnt Signaling Pathway, clinical application, Nerve Regeneration, Neuroinflammation
Received: 02 May 2024; Accepted: 15 Jul 2024.
Copyright: © 2024 Li, Chen, Chang, Xue, Wang and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zanzhi Chen, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
Xuejing Chang, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
Ruiyang Xue, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
Huaibo Wang, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
Weitao Guo, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
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