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REVIEW article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1427054
This article is part of the Research Topic Nervous Regeneration and Functional Recovery in the Central and Peripheral Nervous Systems: Diagnostic Methods, Gene/Cell therapies, and Interventions View all articles

Wnt Signaling Pathway in Spinal Cord Injury: From Mechanisms to Potential Applications

Provisionally accepted
Kai Li Kai Li Zanzhi Chen Zanzhi Chen *Xuejing Chang Xuejing Chang *Ruiyang Xue Ruiyang Xue *Huaibo Wang Huaibo Wang *Weitao Guo Weitao Guo *
  • Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Spinal cord injury (SCI) denotes damage to both the structure and function of the spinal cord, primarily manifesting as sensory and motor deficits caused by disruptions in neural transmission pathways, potentially culminating in irreversible paralysis. Its pathophysiological processes are complex, with numerous molecules and signaling pathways intricately involved. Notably, the pronounced upregulation of the Wnt signaling pathway post-SCI holds promise for neural regeneration and repair.Activation of the Wnt pathway plays a crucial role in neuronal differentiation, axonal regeneration, local neuroinflammatory responses, and cell apoptosis, highlighting its potential as a therapeutic target for treating SCI. However, excessive activation of the Wnt pathway can also lead to negative effects, highlighting the need for further investigation into its applicability and significance in SCI. This paper provides an overview of the latest research advancements in the Wnt signaling pathway in SCI, summarizing the recent progress in treatment strategies associated with the Wnt pathway and analyzing their advantages and disadvantages. Additionally, we offer insights into the clinical application of the Wnt signaling pathway in SCI, along with prospective avenues for future research direction.

    Keywords: spinal cord injury, Wnt Signaling Pathway, clinical application, Nerve Regeneration, Neuroinflammation

    Received: 02 May 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Li, Chen, Chang, Xue, Wang and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zanzhi Chen, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
    Xuejing Chang, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
    Ruiyang Xue, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
    Huaibo Wang, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China
    Weitao Guo, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524003, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.