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REVIEW article

Front. Mol. Neurosci.
Sec. Molecular Signalling and Pathways
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1408949

Multi-faceted Regulation of CREB Family Transcription Factors

Provisionally accepted
Md. Arifur R. Chowdhury Md. Arifur R. Chowdhury Md. Mazedul Haq Md. Mazedul Haq Jeong Hwan Lee Jeong Hwan Lee Sangyun Jeong Sangyun Jeong *
  • Jeonbuk National University, Jeonju, North Jeolla, Republic of Korea

The final, formatted version of the article will be published soon.

    cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear transcription factor, which can be constitutively activated regardless of external stimuli or be inducibly activated by external factors such as stressors, hormones, neurotransmitters, and growth factors. However, CREB controls diverse biological processes including cell growth, differentiation, proliferation, survival, apoptosis in a cell-type-specific manner. The diverse functions of CREB appear to be due to CREBmediated differential gene expression that depends on cAMP response elements and multi-faceted regulation of CREB activity. Indeed, the transcriptional activity of CREB is controlled at several levels including alternative splicing, post-translational modification, dimerization, specific transcriptional coactivators, non-coding small RNAs, and epigenetic regulation. In this review, we present versatile regulatory modes of CREB family transcription factors and discuss their functional consequences.

    Keywords: cAMP responsive element, CREB, Alternative Splicing, Transcriptional coactivator, Posttranscriptional modification, post-translational modification, epigenetic modification

    Received: 04 Apr 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Chowdhury, Haq, Lee and Jeong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sangyun Jeong, Jeonbuk National University, Jeonju, 561-756, North Jeolla, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.