AUTHOR=Cai Minqi , Zheng Qian , Chen Yiqiang , Liu Siyuan , Zhu Huimin , Bai Bing TITLE=Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases JOURNAL=Frontiers in Molecular Neuroscience VOLUME=17 YEAR=2024 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1379726 DOI=10.3389/fnmol.2024.1379726 ISSN=1662-5099 ABSTRACT=

Netrin-1 was initially discovered as a neuronal growth cue for axonal guidance, and its functions have later been identified in inflammation, tumorigenesis, neurodegeneration, and other disorders. We have recently found its alterations in the brains with Alzheimer’s disease, which might provide important clues to the mechanisms of some unique pathologies. To provide better understanding of this promising molecule, we here summarize research progresses in genetics, pathology, biochemistry, cell biology and other studies of Netrin-1 about its mechanistic roles and biomarker potentials with an emphasis on clinical neurodegenerative disorders in order to expand understanding of this promising molecular player in human diseases.