AUTHOR=Dong Hao , Wen Xin , Zhang Bai-Wen , Wu Zhe , Zou Wei 

TITLE=Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=17

YEAR=2024

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1327472

DOI=10.3389/fnmol.2024.1327472

ISSN=1662-5099

ABSTRACT=<p>Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by the intricate interplay of various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class of glial cells, interact with neurons and microglia, and are implicated in a series of pathophysiological alterations following ICH. A comprehensive examination of the functions and mechanisms associated with astrocytic proteins may shed light on the role of astrocytes in ICH pathology and proffer innovative therapeutic avenues for ICH management.</p>