AUTHOR=Greener Megan R. , Storr Sarah J. 

TITLE=Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=16

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1166852

DOI=10.3389/fnmol.2023.1166852

ISSN=1662-5099

ABSTRACT=<p>A lack of cross-disciplinary unanimity prevails within addiction research. Theories conceptualizing addiction through the three-stage brain disease model contest other theories that substance use disorder is of behavioural or genetic origin. The reverberations of this lack of consensus are noticeable throughout addiction research and within the foundations of disease modelling. The availability of methods to investigate substance use disorder are inconsistent and sometimes unrepresentative. This review discusses theories of addiction aetiology, available models for addiction research and the strengths and limitations of current practical experimental methods of study.</p>