AUTHOR=Hou Changkai , Ren Wen , Wang Bangyue , Fu Xi’an , Liu Quanlei , Li Jian , Zhang Hao , Wang Weihan , Yang Xinyu , Wei Penghu , Zhao Guoguang 

TITLE=A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=16

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1148179

DOI=10.3389/fnmol.2023.1148179

ISSN=1662-5099

ABSTRACT=<sec id="sec1"><title>Objective</title><p>To explore the development context, research hotspots and frontiers in the glymphatic system (GS) field from 2012 to 2022 by bibliometric analysis.</p></sec><sec id="sec2"><title>Methods</title><p>The Web of Science Core Collection (WoSCC) database was searched for articles published between 2012 and 2022. Microsoft Excel was used to manage the data. VOSviewer, CiteSpace, GraphPad Prism, the Web of Science, and an online analysis platform for bibliometrics (<ext-link xlink:href="http://bibliometric.com/" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">http://bibliometric.com/</ext-link>) were used to analyze the countries, institutions, journals, and collaboration networks among authors and the types of articles, developmental directions, references, and top keywords of published articles.</p></sec><sec id="sec3"><title>Results</title><p>A total of 412 articles were retrieved, including 39 countries/regions, 223 research institutes and 171 academic journals. The subject classifications related to the GS were Neuroscience, Clinical Neuroscience and Radiology/Nuclear Medicine/Medical Imaging. The United States has maintained its dominant and most influential position in GS research. Among research institutions and journals, the Univ Rochester and Journal of Cerebral Blood Flow and Metabolism had the highest number of academic articles, respectively. Nedergaard M had the most published article, and Iliff JJ had the most co-citations. The top two keywords with the highest frequency were “glymphatic system” and “cerebrospinal fluid.”</p></sec><sec id="sec4"><title>Conclusion</title><p>This research provides valuable information for the study of the GS. The bibliometric analysis of this area will encourage potential collaborations among researchers, defining its frontiers and directions for development.</p></sec>