AUTHOR=Behl Supriya , Mehta Sunil , Pandey Mukesh K. 

TITLE=The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=16

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1130922

DOI=10.3389/fnmol.2023.1130922

ISSN=1662-5099

ABSTRACT=<p>Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function. Most selenoproteins play a large antioxidant role within the brain. Autism spectrum disorder (ASD) has been shown to correlate with increased oxidative stress, and the presumption of selenoproteins as key players in ASD etiology are discussed. Further, current literature surrounding selenium in ASD and selenium supplementation studies are reviewed. Finally, perspectives are given for future directions of selenoprotein research in ASD.</p>