AUTHOR=Lee Soo Yeon , Kweon Hanseul , Kang Hyojin , Kim Eunjoon 

TITLE=Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=16

YEAR=2023

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1111388

DOI=10.3389/fnmol.2023.1111388

ISSN=1662-5099

ABSTRACT=<p><italic>Chd8<sup>+/N2373K</sup></italic> mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, <italic>Chd8<sup>+/S62X</sup></italic> mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female <italic>Chd8<sup>+/S62X</sup></italic> juveniles, respectively, but similarly enhanced in adult male and female mutants. ASD-like transcriptomic changes are stronger in newborn and juvenile (but not adult) <italic>Chd8<sup>+/S62X</sup></italic> males but in newborn and adult (not juvenile) <italic>Chd8<sup>+/S62X</sup></italic> females. These results point to age-differential sexual dimorphisms in <italic>Chd8<sup>+/S62X</sup></italic> mice at synaptic and transcriptomic levels, in addition to the behavioral level.</p>