AUTHOR=Lum Jeremy S. , Yerbury Justin J. TITLE=Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis? JOURNAL=Frontiers in Molecular Neuroscience VOLUME=15 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.997661 DOI=10.3389/fnmol.2022.997661 ISSN=1662-5099 ABSTRACT=
A growing wave of evidence has placed the concept of protein homeostasis at the center of the pathogenesis of amyotrophic lateral sclerosis (ALS). This is due primarily to the presence of pathological transactive response DNA-binding protein (TDP-43), fused in sarcoma (FUS) or