AUTHOR=Godini Rasoul , Fallahi Hossein , Pocock Roger 

TITLE=The regulatory landscape of neurite development in Caenorhabditis elegans

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.974208

DOI=10.3389/fnmol.2022.974208

ISSN=1662-5099

ABSTRACT=<p>Neuronal communication requires precise connectivity of neurite projections (axons and dendrites). Developing neurites express cell-surface receptors that interpret extracellular cues to enable correct guidance toward, and connection with, target cells. Spatiotemporal regulation of neurite guidance molecule expression by transcription factors (TFs) is critical for nervous system development and function. Here, we review how neurite development is regulated by TFs in the <italic>Caenorhabditis elegans</italic> nervous system. By collecting publicly available transcriptome and ChIP-sequencing data, we reveal gene expression dynamics during neurite development, providing insight into transcriptional mechanisms governing construction of the nervous system architecture.</p>