AUTHOR=Wang Ge , Wu Wenyue , Xu Yuchen , Yang Zhuanyi , Xiao Bo , Long Lili TITLE=Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives JOURNAL=Frontiers in Molecular Neuroscience VOLUME=15 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.891621 DOI=10.3389/fnmol.2022.891621 ISSN=1662-5099 ABSTRACT=

Epilepsy is a neurological network disease with genetics playing a much greater role than was previously appreciated. Unfortunately, the relationship between genetic basis and imaging phenotype is by no means simple. Imaging genetics integrates multidimensional datasets within a unified framework, providing a unique opportunity to pursue a global vision for epilepsy. This review delineates the current knowledge of underlying genetic mechanisms for brain networks in different epilepsy syndromes, particularly from a neural developmental perspective. Further, endophenotypes and their potential value are discussed. Finally, we highlight current challenges and provide perspectives for the future development of imaging genetics in epilepsy.