AUTHOR=Sanchez-Conde Francisco G. , Jimenez-Vazquez Eric N. , Auerbach David S. , Jones David K. 

TITLE=The ERG1 K+ Channel and Its Role in Neuronal Health and Disease

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.890368

DOI=10.3389/fnmol.2022.890368

ISSN=1662-5099

ABSTRACT=<p>The ERG1 potassium channel, encoded by <italic>KCNH2</italic>, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1’s relationship to the mammalian brain and highlights key questions that have yet to be answered.</p>