AUTHOR=Wang Na , Lv Longbao , Huang Xiaoyi , Shi Mingqin , Dai Youwu , Wei Yuanyuan , Xu Bonan , Fu Chenyang , Huang Haoyu , Shi Hongling , Liu Yun , Hu Xintian , Qin Dongdong TITLE=Gene editing in monogenic autism spectrum disorder: animal models and gene therapies JOURNAL=Frontiers in Molecular Neuroscience VOLUME=15 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.1043018 DOI=10.3389/fnmol.2022.1043018 ISSN=1662-5099 ABSTRACT=
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disease, and its diagnosis is dependent on behavioral manifestation, such as impaired reciprocal social interactions, stereotyped repetitive behaviors, as well as restricted interests. However, ASD etiology has eluded researchers to date. In the past decades, based on strong genetic evidence including mutations in a single gene, gene editing technology has become an essential tool for exploring the pathogenetic mechanisms of ASD