AUTHOR=Shen Xiao-yue , Shi Shu-han , Li Heng , Wang Cong-cong , Zhang Yao , Yu Hui , Li Yan-bin , Liu Bin 

TITLE=The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.1021207

DOI=10.3389/fnmol.2022.1021207

ISSN=1662-5099

ABSTRACT=<p>Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on Gadd45b has focused chiefly on non-neuronal cells. Gadd45b is extensively expressed in the nervous system and plays a critical role in epigenetic DNA demethylation, neuroplasticity, and neuroprotection, according to accumulating evidence. This article provided an overview of the preclinical and clinical effects of Gadd45b, as well as its hypothesized mechanisms of action, focusing on major psychosis, depression, autism, stroke, seizure, dementia, Parkinson’s disease, and autoimmune diseases of the nervous system.</p>