AUTHOR=Zhang Kexin , Li Pei , Jia Yuanyuan , Liu Ming , Jiang Jingjing TITLE=Non-coding RNA and n6-methyladenosine modification play crucial roles in neuropathic pain JOURNAL=Frontiers in Molecular Neuroscience VOLUME=15 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2022.1002018 DOI=10.3389/fnmol.2022.1002018 ISSN=1662-5099 ABSTRACT=
After peripheral nerve injury, pain signals are transmitted from primary sensory neurons in the dorsal root ganglion (DRG) to the central nervous system. Epigenetic modification affects neuropathic pain through alterations in the gene expression in pain-related areas and glial cell activation. Recent studies have shown that non-coding RNA and n6-methyladenosine (m6A) methylation modification play pivotal regulatory roles in the occurrence and maintenance of neuropathic pain. Dysregulation of the RNA m6A level