AUTHOR=Lan Zhen , Chen Yanting , Jin Jiali , Xu Yun , Zhu Xiaolei 

TITLE=Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=14

YEAR=2022

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.821002

DOI=10.3389/fnmol.2021.821002

ISSN=1662-5099

ABSTRACT=<p>Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most common cause of dementia accounting for an estimated 60–80% of cases. The pathogenesis of AD remains unclear, and no curative treatment is available so far. Increasing evidence has revealed a vital role of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in AD. LncRNAs contribute to the pathogenesis of AD via modulating amyloid production, Tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, synaptic impairment and neuroinflammation. This review describes the biological functions and mechanisms of lncRNAs in AD, indicating that lncRNAs may provide potential therapeutic targets for the diagnosis and treatment of AD.</p>