AUTHOR=Bakaeva Zanda , Lizunova Natalia , Tarzhanov Ivan , Boyarkin Dmitrii , Petrichuk Svetlana , Pinelis Vsevolod , Fisenko Andrey , Tuzikov Alexander , Sharipov Rinat , Surin Alexander TITLE=Lipopolysaccharide From E. coli Increases Glutamate-Induced Disturbances of Calcium Homeostasis, the Functional State of Mitochondria, and the Death of Cultured Cortical Neurons JOURNAL=Frontiers in Molecular Neuroscience VOLUME=14 YEAR=2022 URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.811171 DOI=10.3389/fnmol.2021.811171 ISSN=1662-5099 ABSTRACT=
Lipopolysaccharide (LPS), a fragment of the bacterial cell wall, specifically interacting with protein complexes on the cell surface, can induce the production of pro-inflammatory and apoptotic signaling molecules, leading to the damage and death of brain cells. Similar effects have been noted in stroke and traumatic brain injury, when the leading factor of death is glutamate (Glu) excitotoxicity too. But being an amphiphilic molecule with a significant hydrophobic moiety and a large hydrophilic region, LPS can also non-specifically bind to the plasma membrane, altering its properties. In the present work, we studied the effect of LPS from