AUTHOR=Wang Yujing , Wei Tao , Zhao Wei , Ren Zixuan , Wang Yan , Zhou Yiding , Song Xun , Zhou Ruidong , Zhang Xiaochu , Jiao Dongliang 

TITLE=MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=14

YEAR=2021

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.667725

DOI=10.3389/fnmol.2021.667725

ISSN=1662-5099

ABSTRACT=<p>The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.</p>